SureFarm providing Bovine Tuberculosis Diagnostics using the Enferplex test to the animal health industry



Rhodes S and Vordermeier M. Validation of ante-mortem TB tests in camelids. 28th May 2012.

Whelan C, Shuralev E, O’Keeffe G, et al. Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattle. Clin. Vaccine Immunol. 2008:15;1834–1838.

Whelan C, Whelan AE, Shuralev E, et al. Performance of the Enferplex TB Assay with Cattle in Great Britain and Assessment of Its Suitability as a Test To Distinguish Infected and Vaccinated Animals Clin. Vaccine Immunol. 2010: 813–817

APHA Evidence Project Final Report: SE3263. Validation of new serology tests for bovine tuberculosis in cattle.

Álvarez, J., de Juan, L., Bezos, J., Romero, B., Saez, J.L., Reviriego Gordejo, F.J., Briones, V., Moreno, M.A., Mateos, A., Dominguez, L., Aranaz, A., 2008. Interference of paratuberculosis with the diagnosis of tuberculosis in a goat flock with a natural mixed infection. Veterinary Microbiology 128, 72–80.

Bezos, J, Álvarez, J., Juan, L.D., Romero, B., Rodríguez, S., Castellanos, E., Saéz- Llorente, J.L., Mateos, A., Domínguez, L., Aranaz, A., 2010a. Factors influencing the performance of an interferon-c assay for the diagnosis of tuberculosis

Bezos, J., de Juan, L., Romero, B., Álvarez, J., Mazzucchelli, F., Mateos, A., Dominguez, L., Aranaz, A., 2010b. Experimental infection with Mycobacterium caprae in goats and evaluation of immunological status in tuberculosis and paratuberculosis co-infected animals. Veterinary Immunology and Immunopathology 133, 269–275

Buddle, B.M., Thacker, T.C., Lyashchenko, K.P., Waters, W.R., 2010. Bovine tuberculosis: a review of current and emerging diagnostic techniques in view of their relevance for disease control and eradication. Transboundary and Emerging Diseases 57, 205–220.

Buddle, B.M., Wilson, T., Denis, M., Greenwald, R., Esfandiari, J., Lyashchenko, K.P., Liggett, S., Mackintosh, C.G., 2010. Sensitivity, specificity, and confounding factors of novel serological tests used for the rapid diagnosis of bovine tuberculosis in farmed red deer (Cervus elaphus). Clinical and Vaccine Immunology 17, 626–630.

Crawshaw, T., Daniel, R., Clifton-Hadley, R., Clark, J., Evans, H., Rolfe, S., Rua- Domenech, R., 2008. TB in goats caused by Mycobacterium bovis. Veterinary Record 163, 127.

Daniel, R., Evans, H., Rolfe, S., Rua-Domenech, R., Crawshaw, T., Higgins, R.J., Schock, A., Clifton-Hadley, R., 2009. Outbreak of tuberculosis caused by Mycobacterium bovis in golden Guernsey goats in Great Britain. Veterinary Record 165, 335–342.

de la Rua-Domenech, R., Goodchild, A.T., Vordermeier, M., Hewinson, R.G, Christiansen, K. H., Clifton-Hadley, R.S. (2006) Ante-Mortem diagnosis of tuberculosis in cattle: A review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques. ResVet Sci 81(2) p190-210).

García Marín, F., 1993. Report of meetings of IUATLD scientific committee on tuberculosis in animals, Paris, October 15–16, 1992. In: International Union against Tuberculosis and Lung Disease Newsletter, March 1993, pp. 14–16.

Gutiérrez, M., Tellechea, J., García Marín, J.F., 1998. Evaluation of cellular and serological diagnostic tests for the detection of Mycobacterium bovis-infected goats. Veterinary Microbiology 62, 281–290.

Kohler, H., Gyra, H., Zimmer, K., Drager, K.G., Burkert, B., Lemser, B., Hausleithner, D., Cubler, K., Klawonn, W., Hess, R.G., 2001. Immune reactions in cattle after immunization with a Mycobacterium paratuberculosis vaccine and implications for the diagnosis of M. paratuberculosis and M. bovis infections. Journal of Veterinary Medicine. Series B. Infectious Diseases and Veterinary Public Health 48, 185–195.

Liébana, E., Aranaz, A., Urquia, J.J., Mateos, A., Dominguez, L., 1998. Evaluation of the c-interferon assay for eradication of tuberculosis in a goat herd. Australian Veterinary Journal 76, 50–53.

Mackintosh, C.G., Labes, R.E., Griffin, J.F., 2005. The effect of Johne’s vaccination on tuberculin testing in farmed red deer (Cervus elaphus). New Zealand Veterinary Journal 53, 216–222.

Shuralev, E., Quinn P., Doyle, M. , Duignan, A., Fai Kwok, H., Bezos, H., Olwil, S., Eamonn Gormley, E, Aranaz, A., Good, G., Davis, W., Clarke, J., Whelan, C (2012) Application of the Enfer chemiluminescent multiplex ELISA system for the detection of Mycobacterium bovis infection in goats Veterinary Microbiology 154 (2012) 292–297

Thom et al (2006). The effect of tuberculin testing on the development of cell mediated immunity reponses during Mycobacterium bovis infection  Veterinary Immunology and Immunopathology, 114, 25-36)[1]1.

Vordermeier, M.,  Ewer, K (2006) Specificity Trial of the BOVIGAM® IFN-Gamma Test in GB Cattle”. TB Research Group, Veterinary Laboratories Agency, New Haw, Addlestone  Defra website